Bionano Announces Peer-Reviewed Publication on the Utility of Combining OGM and a 523-gene NGS Panel for Standard Evaluation of Myeloid Cancers
In this blinded retrospective analysis of samples from 30 myeloid cancer subjects, the combination of OGM with the 523-gene NGS panel was compared to the common approach of KT and FISH combined with a 54-gene NGS panel. A pre-commercial version of Bionano’s new NxClinical™ software enabled analysis of OGM and NGS data together, providing an integrated picture of genomic variation. Key findings on the performance of OGM combined with 523-gene panel compared to that of KT and FISH combined with the 54-gene panel are summarized below.
Key findings and their impact in this study | |
OGM identified all SVs detected by KT and FISH | 100% concordance |
OGM found clinically relevant SVs in cases previously classified as normal by KT and FISH | 4 out of 7 cases (57%) |
OGM detected SVs listed in NCCN guidelines that were not identified by KT and FISH | 5 out of 30 cases (16.6%) |
OGM detected SVs listed in the |
4 out of 30 cases (13%) |
The 523-gene panel identified sequence variants of potentially clinical relevance not identified by the 54-gene panel | 6 out of 30 cases (20%) |
OGM combined with 523-gene panel for MDS cases identified compound heterozygous events of clinical significance, including cases where the genes were listed on NCCN guidelines but missed by the KT/FISH and 54-gene panel | 12 out of 30 cases (40%) |
OGM results led to reclassification of cancer from simple to complex | 5 out of 22 cases (23%) |
OGM results with the 523-gene panel for MDS cases led to revisions in IPSS-R risk stratification from very good/good to very poor | 2 out of 9 cases (22%) |
SV = structural variations; NCCN = National Comprehensive Cancer Network; MDS = myelodysplastic syndrome; IPSS-R = Revised International Prognostic Scoring System for MDS Risk Assessment |
“This peer-reviewed publication outlines the potential utility of combining OGM with sequencing panels to evaluate myeloid cancer. I believe this research study shows that OGM can perform significantly better than KT and FISH, which can result in meaningful revisions to various risk classifications and disease stratifications, which are known to affect outcomes. The OGM and sequencing data were analyzed with the upcoming version of our NxClinical analysis software (commercially available as VIA™ analysis software). VIA analysis software will offer a powerful new workflow in cytogenomics and molecular pathology, especially for cancer” commented
The publication can be viewed here https://www.mdpi.com/2072-6694/15/12/3214 and a PDF of it can be downloaded here https://www.mdpi.com/2072-6694/15/12/3214/pdf
About Bionano
Bionano is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Company’s mission is to transform the way the world sees the genome through OGM solutions, diagnostic services and software. The Company offers OGM solutions for applications across basic, translational and clinical research. Through its
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Source: Bionano Genomics